Propagations of eukaryotic cell cultures are relatively long-lasting processes, which makes them sensitive to a greater number of possible contaminants. Among them are:
Viruses are the most dangerous contaminants in this type of fermentation. Due to small sizes, they are the toughest enemy to prevent from entering the process, and their occurrence may result in a very long, lasting even several months, paralysis of whole facility's productivity. Due to the fact that eukaryotic cell cultures are usually used for production of highly valuable products, a risk of running fermentation without optimal protection is something that can cost you a lot.
Bacterial contamination of eukaryotic cell cultures is a problem occuring relatively frequently. Especially well known for contaminating this type of fermentation are mycoplasmas, but other types of bacteria can also act as the causative agents of this problem.
Fungal contamination due to relatively long fermentation process can also pose a problem. When fungi appear in the culture they may cause adverse effects like production of toxins. They are also relatively hard to get rid of due to high resistance of fungal spores.
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